ADAMTS19


Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase with thrombospondin type 1 motif 19MIM:607513Ensembl:ENSG00000145808HGNC:HGNC:17111PA245455q23.3

GO terms in ADAMTS19


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004222metalloendopeptidase activity
MFIEAGO:0046872metal ion binding
BPIEAGO:0006508proteolysis
CCIEAGO:0005576extracellular region

Gene expression in normal tissue: ADAMTS19

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAMTS19


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD505Pevonedistat3
iGMDRD147Prima-11
iGMDRD322FK 8663
iGMDRD286Nsc 6328398
iGMDRD329Merck603
iGMDRD267Oligomycin A3
iGMDRD103SN-383
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD158NSC1415403
iGMDRD211(1S,3R)-RSL33
iGMDRD177Teniposide3
iGMDRD341Triacsin c3
iGMDRD116CD4373
iGMDRD560MK-22061
iGMDRD150RITA3
iGMDRD512nutlin 31
iGMDRD399Selumetinib3
iGMDRD506Fedratinib7
iGMDRD398Sepantronium2
iGMDRD780PP-302
iGMDRD52Rotenone3
iGMDRD870BRD636103
iGMDRD679Bistramide A4
iGMDRD634SCHEMBL26080413
iGMDRD446LY 21832401
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD61Kinetin riboside2
iGMDRD670ML 2103
iGMDRD144NSC953975
iGMDRD494Neopeltolide3
iGMDRD772BRD47702
iGMDRD420Leucascandrolide A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS19

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