ADGRB3


Summary: This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
adhesion G protein-coupled receptor B3MIM:602684Ensembl:ENSG00000135298HGNC:HGNC:945PA252496q12-q13

GO terms in ADGRB3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001965G-protein alpha-subunit binding
MFIBAGO:0004930G-protein coupled receptor activity
MFIEAGO:0004930G-protein coupled receptor activity
MFISSGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
CCIPIGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043083synaptic cleft
CCIEAGO:0043083synaptic cleft
CCIBAGO:0098794postsynapse
CCIEAGO:0098794postsynapse
BPIEAGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007520myoblast fusion
BPIBAGO:0016322neuron remodeling
BPIEAGO:0016322neuron remodeling
BPIEAGO:0016525negative regulation of angiogenesis
BPIEAGO:0043547positive regulation of GTPase activity
BPISSGO:0048814regulation of dendrite morphogenesis
BPIEAGO:0051965positive regulation of synapse assembly
BPIEAGO:0061743motor learning
BPIEAGO:0099558maintenance of synapse structure

Gene expression in normal tissue: ADGRB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADGRB3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD5Tyrphostin AG 14783
iGMDRD137Indisulam6
iGMDRD213SMR0000686502
iGMDRD481Dactolisib1
iGMDRD434BMS-5369245
iGMDRD705Nakiterpiosin2
iGMDRD105Triptolide1
iGMDRD662JQ-17
iGMDRD872BRD71372
iGMDRD286Nsc 6328392
iGMDRD322FK 8662
iGMDRD42Vorinostat4
iGMDRD353PD03259011
iGMDRD246NPC261
iGMDRD886Compound 1541A1
iGMDRD248BRD43542
iGMDRD701NVP-AUY9221
iGMDRD150RITA3
iGMDRD560MK-22061
iGMDRD57Chloropentafluorobenzene1
iGMDRD314Tanespimycin2
iGMDRD85Ursolic acid1
iGMDRD435BI-25362
iGMDRD901ELCPK4
iGMDRD211(1S,3R)-RSL33
iGMDRD613CHEMBL2581481
iGMDRD318PAC-14
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD888Compound 442
iGMDRD224Necrostatin-12
iGMDRD506Fedratinib1
iGMDRD887Compound 23 citrate2
iGMDRD23Gossypol1
iGMDRD64Parbendazole3
iGMDRD772BRD47702
iGMDRD151CHM-11
iGMDRD76Simvastatin3
iGMDRD126Tipifarnib2
iGMDRD494Neopeltolide2
iGMDRD779PRL-3 Inhibitor I1
iGMDRD670ML 2104
iGMDRD61Kinetin riboside4
iGMDRD193Fqi12
iGMDRD446LY 21832402
iGMDRD380Pifithrin-alpha2
iGMDRD634SCHEMBL26080411
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADGRB3

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