AGR3
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| anterior gradient 3, protein disulphide isomerase family member | MIM:609482 | Ensembl:ENSG00000173467 | HGNC:HGNC:24167 | PA162375917 | 7p21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AGR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ND | GO:0008150 | biological_process |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0060548 | negative regulation of cell death |
| CC | ND | GO:0005575 | cellular_component |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IBA | GO:0002162 | dystroglycan binding |
| MF | IDA | GO:0002162 | dystroglycan binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: AGR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGR3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGR3
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.