AKAP12
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-kinase anchoring protein 12 | MIM:604698 | Ensembl:ENSG00000131016 | HGNC:HGNC:370 | PA24664 | 6q25.1 |
GO terms in AKAP12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006605 | protein targeting |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0010738 | regulation of protein kinase A signaling |
| BP | IEA | GO:0010739 | positive regulation of protein kinase A signaling |
| BP | IEA | GO:0090036 | regulation of protein kinase C signaling |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0005938 | cell cortex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008179 | adenylate cyclase binding |
| MF | IEA | GO:0051018 | protein kinase A binding |
Gene expression in normal tissue: AKAP12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD598 | QS-11 | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP12
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