AKAP4
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-kinase anchoring protein 4 | MIM:300185 | Ensembl:ENSG00000147081 | HGNC:HGNC:374 | PA24668 | Xp11.22 |
GO terms in AKAP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0051018 | protein kinase A binding |
| MF | ISS | GO:0051018 | protein kinase A binding |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | NAS | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | IEA | GO:0030018 | Z disc |
| CC | IDA | GO:0031514 | motile cilium |
| CC | IBA | GO:0035686 | sperm fibrous sheath |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IBA | GO:0097228 | sperm principal piece |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| BP | TAS | GO:0007338 | single fertilization |
| BP | IBA | GO:0010738 | regulation of protein kinase A signaling |
| BP | IMP | GO:0030317 | flagellated sperm motility |
| BP | IEA | GO:0044458 | motile cilium assembly |
| BP | IEA | GO:0045184 | establishment of protein localization |
Gene expression in normal tissue: AKAP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP4
CLASSFICATION
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