Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011].

aldehyde dehydrogenase 1 family member A2MIM:603687Ensembl:ENSG00000128918HGNC:HGNC:15472PA2469315q21.3

Gene Categories:


GO terms in ALDH1A2

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0048471perinuclear region of cytoplasm
BPIEAGO:0001568blood vessel development
BPIEAGO:0001822kidney development
BPIEAGO:0001889liver development
BPIEAGO:0001936regulation of endothelial cell proliferation
BPIEAGO:0003007heart morphogenesis
BPNASGO:0006776vitamin A metabolic process
BPIEAGO:0007494midgut development
BPIEAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0009855determination of bilateral symmetry
BPIEAGO:0009954proximal/distal pattern formation
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0014032neural crest cell development
BPIEAGO:0016331morphogenesis of embryonic epithelium
BPIMPGO:0021915neural tube development
BPIEAGO:0021983pituitary gland development
BPIEAGO:0030182neuron differentiation
BPIEAGO:0030324lung development
BPIEAGO:0030902hindbrain development
BPIEAGO:0031016pancreas development
BPIEAGO:0031076embryonic camera-type eye development
BPIEAGO:0032355response to estradiol
BPIEAGO:0033189response to vitamin A
BPIDAGO:0034097response to cytokine
BPIEAGO:0035115embryonic forelimb morphogenesis
BPIEAGO:0035799ureter maturation
BPIEAGO:0042572retinol metabolic process
BPISSGO:0042573retinoic acid metabolic process
BPIEAGO:0042574retinal metabolic process
BPIEAGO:00429049-cis-retinoic acid biosynthetic process
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0048566embryonic digestive tract development
BPIEAGO:0048738cardiac muscle tissue development
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0060324face development
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0090242retinoic acid receptor signaling pathway involved in somitogenesis
MFISSGO:0001758retinal dehydrogenase activity
MFTASGO:0001758retinal dehydrogenase activity
MFISSGO:00040283-chloroallyl aldehyde dehydrogenase activity
MFIBAGO:0004029aldehyde dehydrogenase (NAD) activity
MFISSGO:0016918retinal binding

Gene expression in normal tissue: ALDH1A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALDH1A2

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-5365859RA biosynthesis pathway
reactomeR-HSA-9006931Signaling by Nuclear Receptors
kegghsa00830Retinol metabolism - Homo sapiens (human)
humancycPWY-6872retinoate biosynthesis I
wikipathwaysWP3996Ethanol effects on histone modifications
wikipathwaysWP465Tryptophan metabolism
wikipathwaysWP716Vitamin A and Carotenoid Metabolism
smpdbSMP00074Retinol Metabolism
smpdbSMP00336Vitamin A Deficiency

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD162All-trans Retinoic Acid1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALDH1A2