ALDH3B1
Summary: This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 3 family member B1 | MIM:600466 | Ensembl:ENSG00000006534 | HGNC:HGNC:410 | PA24699 | 11q13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ALDH3B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006066 | alcohol metabolic process |
| BP | IEA | GO:0006068 | ethanol catabolic process |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IDA | GO:0034599 | cellular response to oxidative stress |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0046185 | aldehyde catabolic process |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| MF | IBA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | TAS | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | IEA | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IDA | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity |
| MF | TAS | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ALDH3B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALDH3B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-0 | putrescine degradation III |
| humancyc | PWY-7180 | 2,-deoxy-α-D-ribose 1-phosphate degradation |
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00340 | Histidine metabolism - Homo sapiens (human) |
| kegg | hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| kegg | hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| kegg | hsa00410 | beta-Alanine metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALDH3B1
CLASSFICATION
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