ALDH3B1


Summary: This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
aldehyde dehydrogenase 3 family member B1MIM:600466Ensembl:ENSG00000006534HGNC:HGNC:410PA2469911q13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in ALDH3B1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIEAGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCTASGO:0030667secretory granule membrane
CCHDAGO:0031982vesicle
CCTASGO:0035579specific granule membrane
CCHDAGO:0070062extracellular exosome
BPTASGO:0006066alcohol metabolic process
BPIEAGO:0006068ethanol catabolic process
BPTASGO:0006629lipid metabolic process
BPTASGO:0030148sphingolipid biosynthetic process
BPIDAGO:0034599cellular response to oxidative stress
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0046185aldehyde catabolic process
BPIDAGO:0055114oxidation-reduction process
MFIBAGO:00040283-chloroallyl aldehyde dehydrogenase activity
MFTASGO:00040283-chloroallyl aldehyde dehydrogenase activity
MFIEAGO:0004029aldehyde dehydrogenase (NAD) activity
MFIDAGO:0004030aldehyde dehydrogenase [NAD(P)+] activity
MFTASGO:0004030aldehyde dehydrogenase [NAD(P)+] activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: ALDH3B1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALDH3B1


DatabasePathway IDPathway Des.
humancycPWY-0putrescine degradation III
humancycPWY-71802,-deoxy-α-D-ribose 1-phosphate degradation
kegghsa00010Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegghsa00340Histidine metabolism - Homo sapiens (human)
kegghsa00350Tyrosine metabolism - Homo sapiens (human)
kegghsa00360Phenylalanine metabolism - Homo sapiens (human)
kegghsa00410beta-Alanine metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALDH3B1

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