APBB1IP
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| amyloid beta precursor protein binding family B member 1 interacting protein | MIM:609036 | Ensembl:ENSG00000077420 | HGNC:HGNC:17379 | PA134933955 | 10p12.1 |
GO terms in APBB1IP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0042101 | T cell receptor complex |
| BP | IEA | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0045785 | positive regulation of cell adhesion |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: APBB1IP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APBB1IP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3945 | TYROBP Causal Network |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD144 | NSC95397 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APBB1IP
CLASSFICATION
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