Summary: The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

ADP ribosylation factor GTPase activating protein 1MIM:608377Ensembl:ENSG00000101199HGNC:HGNC:15852PA16474124620q13.33

GO terms in ARFGAP1

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0000139Golgi membrane
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0014069postsynaptic density
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIEAGO:0015031protein transport
BPIBAGO:0030100regulation of endocytosis
BPIEAGO:0030100regulation of endocytosis
BPTASGO:0036498IRE1-mediated unfolded protein response
BPIEAGO:0043547positive regulation of GTPase activity

Gene expression in normal tissue: ARFGAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARFGAP1

DatabasePathway IDPathway Des.
biocartaarappathwayadp-ribosylation factor
biocartarac1pathwayrac1 cell motility signaling pathway
biocartarhopathwayrho cell motility signaling pathway
biocartatcrpathwayt cell receptor signaling pathway
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
wikipathwaysWP3472XBP1(S) activates chaperone genes
pidarf_3pathwayArf1 pathway
kegghsa04144Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD218XAV 9391
iGMDRD281Vinorelbine base1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARFGAP1