ARID4A
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AT-rich interaction domain 4A | MIM:180201 | Ensembl:ENSG00000032219 | HGNC:HGNC:9885 | PA34249 | 14q23.1 |
Gene Categories:
HISTONE MODIFICATIONGO terms in ARID4A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| BP | IEA | GO:0006349 | regulation of gene expression by genetic imprinting |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0016575 | histone deacetylation |
| BP | IEA | GO:0034773 | histone H4-K20 trimethylation |
| BP | IEA | GO:0036124 | histone H3-K9 trimethylation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048821 | erythrocyte development |
| BP | IEA | GO:0080182 | histone H3-K4 trimethylation |
| BP | IEA | GO:0097368 | establishment of Sertoli cell barrier |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
Gene expression in normal tissue: ARID4A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARID4A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARID4A
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