ARID4A


Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
AT-rich interaction domain 4AMIM:180201Ensembl:ENSG00000032219HGNC:HGNC:9885PA3424914q23.1

Gene Categories:

HISTONE MODIFICATION

GO terms in ARID4A


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0017053transcriptional repressor complex
BPIEAGO:0006349regulation of gene expression by genetic imprinting
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0007283spermatogenesis
BPIEAGO:0016575histone deacetylation
BPIEAGO:0034773histone H4-K20 trimethylation
BPIEAGO:0036124histone H3-K9 trimethylation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048821erythrocyte development
BPIEAGO:0080182histone H3-K4 trimethylation
BPIEAGO:0097368establishment of Sertoli cell barrier
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0004407histone deacetylase activity
MFIBAGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: ARID4A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARID4A


DatabasePathway IDPathway Des.
reactomeR-HSA-3214815HDACs deacetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD455Idelalisib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARID4A

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