ATG7
Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| autophagy related 7 | MIM:608760 | Ensembl:ENSG00000197548 | HGNC:HGNC:16935 | PA134983397 | 3p25.3 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in ATG7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004839 | ubiquitin activating enzyme activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0019778 | Atg12 activating enzyme activity |
| MF | ISS | GO:0019778 | Atg12 activating enzyme activity |
| MF | IBA | GO:0019779 | Atg8 activating enzyme activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005930 | axoneme |
| CC | IEA | GO:0030424 | axon |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | IBA | GO:0000045 | autophagosome assembly |
| BP | IBA | GO:0000422 | autophagy of mitochondrion |
| BP | IGI | GO:0000422 | autophagy of mitochondrion |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IDA | GO:0006497 | protein lipidation |
| BP | IBA | GO:0006501 | C-terminal protein lipidation |
| BP | IMP | GO:0006914 | autophagy |
| BP | IBA | GO:0006995 | cellular response to nitrogen starvation |
| BP | IEA | GO:0007568 | aging |
| BP | IDA | GO:0009267 | cellular response to starvation |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0010508 | positive regulation of autophagy |
| BP | IEA | GO:0015031 | protein transport |
| BP | IMP | GO:0016236 | macroautophagy |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0031401 | positive regulation of protein modification process |
| BP | IBA | GO:0034727 | piecemeal microautophagy of the nucleus |
| BP | IMP | GO:0039521 | suppression by virus of host autophagy |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0044805 | late nucleophagy |
| BP | IMP | GO:0045732 | positive regulation of protein catabolic process |
| BP | IMP | GO:0051607 | defense response to virus |
| BP | TAS | GO:0061025 | membrane fusion |
| BP | IEA | GO:0071315 | cellular response to morphine |
| BP | IDA | GO:0071455 | cellular response to hyperoxia |
| BP | IGI | GO:0075044 | autophagy of host cells involved in interaction with symbiont |
| BP | IEA | GO:0090298 | negative regulation of mitochondrial DNA replication |
| BP | IEA | GO:1902617 | response to fluoride |
| BP | IEA | GO:1903204 | negative regulation of oxidative stress-induced neuron death |
Gene expression in normal tissue: ATG7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATG7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATG7
CLASSFICATION
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