ATG7


Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
autophagy related 7MIM:608760Ensembl:ENSG00000197548HGNC:HGNC:16935PA1349833973p25.3

GO terms in ATG7


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004839ubiquitin activating enzyme activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0019778Atg12 activating enzyme activity
MFISSGO:0019778Atg12 activating enzyme activity
MFIBAGO:0019779Atg8 activating enzyme activity
MFIDAGO:0042803protein homodimerization activity
CCIBAGO:0000407phagophore assembly site
CCTASGO:0005576extracellular region
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCISSGO:0005930axoneme
CCIEAGO:0030424axon
CCTASGO:0034774secretory granule lumen
CCTASGO:1904813ficolin-1-rich granule lumen
BPIBAGO:0000045autophagosome assembly
BPIBAGO:0000422autophagy of mitochondrion
BPIGIGO:0000422autophagy of mitochondrion
BPTASGO:0006464cellular protein modification process
BPIDAGO:0006497protein lipidation
BPIBAGO:0006501C-terminal protein lipidation
BPIMPGO:0006914autophagy
BPIBAGO:0006995cellular response to nitrogen starvation
BPIEAGO:0007568aging
BPIDAGO:0009267cellular response to starvation
BPIEAGO:0009749response to glucose
BPIEAGO:0010508positive regulation of autophagy
BPIEAGO:0015031protein transport
BPIMPGO:0016236macroautophagy
BPTASGO:0016236macroautophagy
BPIEAGO:0016567protein ubiquitination
BPIDAGO:0031401positive regulation of protein modification process
BPIBAGO:0034727piecemeal microautophagy of the nucleus
BPIMPGO:0039521suppression by virus of host autophagy
BPIMPGO:0043065positive regulation of apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0044805late nucleophagy
BPIMPGO:0045732positive regulation of protein catabolic process
BPIMPGO:0051607defense response to virus
BPTASGO:0061025membrane fusion
BPIEAGO:0071315cellular response to morphine
BPIDAGO:0071455cellular response to hyperoxia
BPIGIGO:0075044autophagy of host cells involved in interaction with symbiont
BPIEAGO:0090298negative regulation of mitochondrial DNA replication
BPIEAGO:1902617response to fluoride
BPIEAGO:1903204negative regulation of oxidative stress-induced neuron death

Gene expression in normal tissue: ATG7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATG7


DatabasePathway IDPathway Des.
kegghsa04136Autophagy - other - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04216Ferroptosis - Homo sapiens (human)
wikipathwaysWP2509Nanoparticle triggered autophagic cell death
wikipathwaysWP615Senescence and Autophagy in Cancer
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1632852Macroautophagy
reactomeR-HSA-1632852Macroautophagy
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATG7

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