BAK1
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 antagonist/killer 1 | MIM:600516 | Ensembl:ENSG00000030110 | HGNC:HGNC:949 | PA25253 | 6p21.31 |
GO terms in BAK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0051087 | chaperone binding |
| MF | IEA | GO:0051400 | BH domain binding |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005829 | cytosol |
| CC | ISS | GO:0031307 | integral component of mitochondrial outer membrane |
| CC | IDA | GO:0046930 | pore complex |
| CC | IDA | GO:0097145 | BAK complex |
| BP | IEA | GO:0001782 | B cell homeostasis |
| BP | IEA | GO:0001783 | B cell apoptotic process |
| BP | IDA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | IGI | GO:0001836 | release of cytochrome c from mitochondria |
| BP | IEA | GO:0001974 | blood vessel remodeling |
| BP | IEA | GO:0002262 | myeloid cell homeostasis |
| BP | IEA | GO:0002352 | B cell negative selection |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008053 | mitochondrial fusion |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
| BP | IEA | GO:0009620 | response to fungus |
| BP | IEA | GO:0010046 | response to mycotoxin |
| BP | IEA | GO:0010225 | response to UV-C |
| BP | IDA | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| BP | IEA | GO:0010332 | response to gamma radiation |
| BP | IEA | GO:0010524 | positive regulation of calcium ion transport into cytosol |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0031018 | endocrine pancreas development |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | TAS | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
| BP | IEA | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| BP | IEA | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0034620 | cellular response to unfolded protein |
| BP | IMP | GO:0034644 | cellular response to UV |
| BP | ISS | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035108 | limb morphogenesis |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043496 | regulation of protein homodimerization activity |
| BP | IDA | GO:0043497 | regulation of protein heterodimerization activity |
| BP | IEA | GO:0044346 | fibroblast apoptotic process |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IDA | GO:0045862 | positive regulation of proteolysis |
| BP | IDA | GO:0046902 | regulation of mitochondrial membrane permeability |
| BP | IEA | GO:0048597 | post-embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IDA | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IEA | GO:0060068 | vagina development |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEA | GO:0070242 | thymocyte apoptotic process |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IMP | GO:0097190 | apoptotic signaling pathway |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IDA | GO:0097202 | activation of cysteine-type endopeptidase activity |
| BP | IMP | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response |
| BP | TAS | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| BP | IEA | GO:1902262 | apoptotic process involved in blood vessel morphogenesis |
| BP | TAS | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
Gene expression in normal tissue: BAK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111452 | Activation and oligomerization of BAK protein |
| reactome | R-HSA-111457 | Release of apoptotic factors from the mitochondria |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD23 | Gossypol | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAK1
CLASSFICATION
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