Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008].

BCL2 antagonist/killer 1MIM:600516Ensembl:ENSG00000030110HGNC:HGNC:949PA252536p21.31

GO terms in BAK1

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0031072heat shock protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0044325ion channel binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIEAGO:0051087chaperone binding
MFIEAGO:0051400BH domain binding
CCIBAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIEAGO:0005783endoplasmic reticulum
CCISSGO:0031307integral component of mitochondrial outer membrane
CCIDAGO:0046930pore complex
CCIDAGO:0097145BAK complex
BPIEAGO:0001782B cell homeostasis
BPIEAGO:0001783B cell apoptotic process
BPIDAGO:0001836release of cytochrome c from mitochondria
BPIGIGO:0001836release of cytochrome c from mitochondria
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0002262myeloid cell homeostasis
BPIEAGO:0002352B cell negative selection
BPIDAGO:0006915apoptotic process
BPNASGO:0006915apoptotic process
BPIEAGO:0007420brain development
BPIEAGO:0008053mitochondrial fusion
BPIEAGO:0008283cell proliferation
BPIEAGO:0008285negative regulation of cell proliferation
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
BPIEAGO:0009620response to fungus
BPIEAGO:0010046response to mycotoxin
BPIEAGO:0010225response to UV-C
BPIDAGO:0010248establishment or maintenance of transmembrane electrochemical gradient
BPIEAGO:0010332response to gamma radiation
BPIEAGO:0010524positive regulation of calcium ion transport into cytosol
BPIEAGO:0010629negative regulation of gene expression
BPIEAGO:0014070response to organic cyclic compound
BPIEAGO:0031018endocrine pancreas development
BPIEAGO:0031100animal organ regeneration
BPTASGO:0032469endoplasmic reticulum calcium ion homeostasis
BPIEAGO:0032471negative regulation of endoplasmic reticulum calcium ion concentration
BPIEAGO:0033137negative regulation of peptidyl-serine phosphorylation
BPTASGO:0034620cellular response to unfolded protein
BPIMPGO:0034644cellular response to UV
BPISSGO:0034644cellular response to UV
BPIEAGO:0035108limb morphogenesis
BPIEAGO:0042542response to hydrogen peroxide
BPIMPGO:0043065positive regulation of apoptotic process
BPISSGO:0043065positive regulation of apoptotic process
BPIDAGO:0043496regulation of protein homodimerization activity
BPIDAGO:0043497regulation of protein heterodimerization activity
BPIEAGO:0044346fibroblast apoptotic process
BPIEAGO:0045471response to ethanol
BPIDAGO:0045862positive regulation of proteolysis
BPIDAGO:0046902regulation of mitochondrial membrane permeability
BPIEAGO:0048597post-embryonic camera-type eye morphogenesis
BPIEAGO:0051726regulation of cell cycle
BPIDAGO:0051881regulation of mitochondrial membrane potential
BPIEAGO:0060068vagina development
BPTASGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIEAGO:0070242thymocyte apoptotic process
BPIEPGO:0071260cellular response to mechanical stimulus
BPIEAGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:0097190apoptotic signaling pathway
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIDAGO:0097202activation of cysteine-type endopeptidase activity
BPIMPGO:1900103positive regulation of endoplasmic reticulum unfolded protein response
BPTASGO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BPIEAGO:1902262apoptotic process involved in blood vessel morphogenesis
BPTASGO:1903896positive regulation of IRE1-mediated unfolded protein response

Gene expression in normal tissue: BAK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAK1

DatabasePathway IDPathway Des.
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111452Activation and oligomerization of BAK protein
reactomeR-HSA-111457Release of apoptotic factors from the mitochondria
reactomeR-HSA-5357801Programmed Cell Death
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP710DNA Damage Response (only ATM dependent)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAK1