Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015].

B cell CLL/lymphoma 6MIM:109565Ensembl:ENSG00000113916HGNC:HGNC:1001PA253123q27.3

GO terms in BCL6

Term TypeEvidence TypeGO Term IDGO Des.
BPIGIGO:0000060protein import into nucleus, translocation
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001953negative regulation of cell-matrix adhesion
BPIEAGO:0002467germinal center formation
BPNASGO:0002634regulation of germinal center formation
BPNASGO:0002903negative regulation of B cell apoptotic process
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006954inflammatory response
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007266Rho protein signal transduction
BPIEAGO:0008285negative regulation of cell proliferation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030036actin cytoskeleton organization
BPIEAGO:0030183B cell differentiation
BPIDAGO:0030308negative regulation of cell growth
BPIEAGO:0030890positive regulation of B cell proliferation
BPIEAGO:0031065positive regulation of histone deacetylation
BPIEAGO:0032764negative regulation of mast cell cytokine production
BPIEAGO:0035024negative regulation of Rho protein signal transduction
BPIBAGO:0042092type 2 immune response
BPIBAGO:0042127regulation of cell proliferation
BPTASGO:0042981regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043087regulation of GTPase activity
BPIEAGO:0043380regulation of memory T cell differentiation
BPIMPGO:0045591positive regulation of regulatory T cell differentiation
BPIBAGO:0045595regulation of cell differentiation
BPIEAGO:0045629negative regulation of T-helper 2 cell differentiation
BPIEAGO:0045666positive regulation of neuron differentiation
BPIEAGO:0045746negative regulation of Notch signaling pathway
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPNASGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0048294negative regulation of isotype switching to IgE isotypes
BPIEAGO:0048821erythrocyte development
BPIBAGO:0050727regulation of inflammatory response
BPNASGO:0050776regulation of immune response
BPIEAGO:0051272positive regulation of cellular component movement
BPNASGO:1903464negative regulation of mitotic cell cycle DNA replication
BPIEAGO:2000773negative regulation of cellular senescence
CCIDAGO:0005657replication fork
CCIDAGO:0005794Golgi apparatus
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIEAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001161intronic transcription regulatory region sequence-specific DNA binding
MFIBAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003677DNA binding
MFIDAGO:0003682chromatin binding
MFIMPGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0031490chromatin DNA binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: BCL6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL6

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidfoxopathwayFoxO family signaling
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidil4_2pathwayIL4-mediated signaling events
pidp53downstreampathwayDirect p53 effectors
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside2
iGMDRD584VER 1550081

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL6