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BLVRB

Summary: The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
biliverdin reductase B	MIM:600941	Ensembl:ENSG00000090013	HGNC:HGNC:1063	PA25374	19q13.2

GO terms in BLVRB

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IEA	GO:0043195	terminal bouton
CC	HDA	GO:0070062	extracellular exosome
BP	IDA	GO:0042167	heme catabolic process
BP	TAS	GO:0042167	heme catabolic process
BP	IEA	GO:0055114	oxidation-reduction process
MF	IDA	GO:0004074	biliverdin reductase activity
MF	TAS	GO:0004074	biliverdin reductase activity
MF	IDA	GO:0042602	riboflavin reductase (NADPH) activity

Gene expression in normal tissue: BLVRB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BLVRB

Database	Pathway ID	Pathway Des.
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP2884	NRF2 pathway
kegg	hsa00740	Riboflavin metabolism - Homo sapiens (human)
kegg	hsa00860	Porphyrin and chlorophyll metabolism - Homo sapiens (human)
pharmgkb	PA165980834	Methylene Blue Pathway, Pharmacodynamics
humancyc	PWY-5874	heme degradation
biocarta	il10pathway	il-10 anti-inflammatory signaling pathway
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-189445	Metabolism of porphyrins
reactome	R-HSA-189483	Heme degradation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BLVRB

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CLASSFICATION

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