BYSL


Summary: Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
bystin likeMIM:603871Ensembl:ENSG00000112578HGNC:HGNC:1157PA254726p21.1

GO terms in BYSL


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BPIEAGO:0001829trophectodermal cell differentiation
BPIBAGO:0006364rRNA processing
BPTASGO:0007155cell adhesion
BPTASGO:0007565female pregnancy
BPIEAGO:0008283cell proliferation
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005730nucleolus
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCIBAGO:0030688preribosome, small subunit precursor
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0045177apical part of cell
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0030515snoRNA binding

Gene expression in normal tissue: BYSL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BYSL


DatabasePathway IDPathway Des.
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BYSL

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