CASP10


Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caspase 10MIM:601762Ensembl:ENSG00000003400HGNC:HGNC:1500PA260842q33.1

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in CASP10


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0031265CD95 death-inducing signaling complex
CCIDAGO:0097342ripoptosome
BPIEAGO:0006508proteolysis
BPIBAGO:0006915apoptotic process
BPTASGO:0006915apoptotic process
BPIBAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0042981regulation of apoptotic process
BPIMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0097190apoptotic signaling pathway
BPIBAGO:0097194execution phase of apoptosis
MFIDAGO:0004197cysteine-type endopeptidase activity
MFIPIGO:0005515protein binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0035877death effector domain binding
MFIBAGO:0097153cysteine-type endopeptidase activity involved in apoptotic process
MFIBAGO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway
MFIMPGO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway
MFIBAGO:0097200cysteine-type endopeptidase activity involved in execution phase of apoptosis

Gene expression in normal tissue: CASP10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASP10


DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP254Apoptosis
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP3865RIG-I-like Receptor Signaling
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidfaspathwayFAS (CD95) signaling pathway
pidp53downstreampathwayDirect p53 effectors
pidtrail_pathwayTRAIL signaling pathway
netpathPathway_TNFalphaTNFalpha
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
biocartacaspasepathwaycaspase cascade in apoptosis
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartafaspathwayfas signaling pathway (cd95)
biocartairespathwayinternal ribosome entry pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75157FasL/ CD95L signaling
reactomeR-HSA-75158TRAIL signaling
reactomeR-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD405PIK-753
iGMDRD420Leucascandrolide A3
iGMDRD154NSC237661
iGMDRD123Isoevodiamine3
iGMDRD466Chaetocin3
iGMDRD901ELCPK3
iGMDRD213SMR0000686503
iGMDRD267Oligomycin A1
iGMDRD52Rotenone3
iGMDRD171Pemetrexed3
iGMDRD705Nakiterpiosin3
iGMDRD121GMX17783
iGMDRD103SN-383
iGMDRD451Serdemetan3
iGMDRD356PNU-746543
iGMDRD64Parbendazole3
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate3
iGMDRD414MST-3123
iGMDRD100Zebularine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP10

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