CBFA2T3
Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CBFA2/RUNX1 translocation partner 3 | MIM:603870 | Ensembl:ENSG00000129993 | HGNC:HGNC:1537 | PA26113 | 16q24.3 |
GO terms in CBFA2T3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0030851 | granulocyte differentiation |
| BP | IMP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0045820 | negative regulation of glycolytic process |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:1903715 | regulation of aerobic respiration |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
Gene expression in normal tissue: CBFA2T3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBFA2T3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| pid | erbb4_pathway | ErbB4 signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 4 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD201 | SKI II | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD802 | 4-methylfasudil | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CBFA2T3
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.