CBFA2T3


Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CBFA2/RUNX1 translocation partner 3MIM:603870Ensembl:ENSG00000129993HGNC:HGNC:1537PA2611316q24.3

GO terms in CBFA2T3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003700DNA-binding transcription factor activity
MFIBAGO:0003714transcription corepressor activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
BPIDAGO:0001666response to hypoxia
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0008283cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0030851granulocyte differentiation
BPIMPGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0045820negative regulation of glycolytic process
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:1903715regulation of aerobic respiration
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus

Gene expression in normal tissue: CBFA2T3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CBFA2T3


DatabasePathway IDPathway Des.
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
piderbb4_pathwayErbB4 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD177Teniposide4
iGMDRD154NSC237666
iGMDRD351GW843682X1
iGMDRD314Tanespimycin5
iGMDRD532Olaparib3
iGMDRD405PIK-752
iGMDRD307Manumycin A6
iGMDRD48Dexamethasone3
iGMDRD148Pifithrin-mu1
iGMDRD147Prima-13
iGMDRD300Tozasertib3
iGMDRD353PD03259011
iGMDRD82Quiflapon3
iGMDRD872BRD71372
iGMDRD286Nsc 6328395
iGMDRD366PI-1034
iGMDRD329Merck602
iGMDRD434BMS-5369244
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide3
iGMDRD267Oligomycin A2
iGMDRD137Indisulam2
iGMDRD202Curcumin3
iGMDRD158NSC1415406
iGMDRD679Bistramide A2
iGMDRD375GW-4058332
iGMDRD201SKI II6
iGMDRD446LY 21832402
iGMDRD163all trans Retinoic Acid3
iGMDRD144NSC953972
iGMDRD781Sirolimus5
iGMDRD554CHEMBL14341371
iGMDRD126Tipifarnib2
iGMDRD772BRD47703
iGMDRD1008SR-II-138A3
iGMDRD889Compound 7d-cis3
iGMDRD60Quinoclamine2
iGMDRD524ISX-93
iGMDRD451Serdemetan2
iGMDRD356PNU-746541
iGMDRD23Gossypol3
iGMDRD268Cerulenin3
iGMDRD598QS-113
iGMDRD74Idarubicin5
iGMDRD188Piperlongumine5
iGMDRD100Zebularine3
iGMDRD562Navitoclax3
iGMDRD506Fedratinib3
iGMDRD577BIX012946
iGMDRD171Pemetrexed4
iGMDRD187BRD98764
iGMDRD885Compound 1103
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD474Avrainvillamide6
iGMDRD8024-methylfasudil2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CBFA2T3

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