CBX1


Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
chromobox 1MIM:604511Ensembl:ENSG00000108468HGNC:HGNC:1551PA2612617q21.32

GO terms in CBX1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003682chromatin binding
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0042803protein homodimerization activity
MFIPIGO:1990226histone methyltransferase binding
BPIEAGO:0045892negative regulation of transcription, DNA-templated
CCIDAGO:0000775chromosome, centromeric region
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000785chromatin
CCIEAGO:0001939female pronucleus
CCIEAGO:0001940male pronucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCTASGO:0005720nuclear heterochromatin
CCIEAGO:0005721pericentric heterochromatin
CCIDAGO:0005819spindle
CCIEAGO:0010369chromocenter

Gene expression in normal tissue: CBX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CBX1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CBX1

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