CBX1
Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromobox 1 | MIM:604511 | Ensembl:ENSG00000108468 | HGNC:HGNC:1551 | PA26126 | 17q21.32 |
GO terms in CBX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:1990226 | histone methyltransferase binding |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| CC | IDA | GO:0000775 | chromosome, centromeric region |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000785 | chromatin |
| CC | IEA | GO:0001939 | female pronucleus |
| CC | IEA | GO:0001940 | male pronucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005720 | nuclear heterochromatin |
| CC | IEA | GO:0005721 | pericentric heterochromatin |
| CC | IDA | GO:0005819 | spindle |
| CC | IEA | GO:0010369 | chromocenter |
Gene expression in normal tissue: CBX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBX1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CBX1
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