CD2BP2
Summary: This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD2 cytoplasmic tail binding protein 2 | MIM:604470 | Ensembl:ENSG00000169217 | HGNC:HGNC:1656 | PA26209 | 16p11.2 |
GO terms in CD2BP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0043021 | ribonucleoprotein complex binding |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005682 | U5 snRNP |
| CC | IDA | GO:0005682 | U5 snRNP |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| BP | NAS | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0010923 | negative regulation of phosphatase activity |
Gene expression in normal tissue: CD2BP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD2BP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD2BP2
CLASSFICATION
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