CD34
Summary: The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD34 molecule | MIM:142230 | Ensembl:ENSG00000174059 | HGNC:HGNC:1662 | PA26211 | 1q32.2 |
GO terms in CD34
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0030246 | carbohydrate binding |
| MF | IEA | GO:0043199 | sulfate binding |
| BP | IDA | GO:0001894 | tissue homeostasis |
| BP | IDA | GO:0001935 | endothelial cell proliferation |
| BP | IEP | GO:0003094 | glomerular filtration |
| BP | IEP | GO:0003158 | endothelium development |
| BP | IBA | GO:0007160 | cell-matrix adhesion |
| BP | IEP | GO:0007165 | signal transduction |
| BP | IDA | GO:0008217 | regulation of blood pressure |
| BP | ISS | GO:0008283 | cell proliferation |
| BP | IEP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0030097 | hemopoiesis |
| BP | IDA | GO:0030195 | negative regulation of blood coagulation |
| BP | IDA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032733 | positive regulation of interleukin-10 production |
| BP | ISS | GO:0035759 | mesangial cell-matrix adhesion |
| BP | IDA | GO:0038001 | paracrine signaling |
| BP | IDA | GO:0042482 | positive regulation of odontogenesis |
| BP | IDA | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IEP | GO:0048870 | cell motility |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | ISS | GO:0050900 | leukocyte migration |
| BP | IEP | GO:0060290 | transdifferentiation |
| BP | IEP | GO:0061042 | vascular wound healing |
| BP | IMP | GO:0071425 | hematopoietic stem cell proliferation |
| BP | IDA | GO:0071636 | positive regulation of transforming growth factor beta production |
| BP | IDA | GO:0071657 | positive regulation of granulocyte colony-stimulating factor production |
| BP | IEP | GO:0071657 | positive regulation of granulocyte colony-stimulating factor production |
| BP | IDA | GO:0071971 | extracellular exosome assembly |
| BP | IEP | GO:0072011 | glomerular endothelium development |
| BP | IEP | GO:0072089 | stem cell proliferation |
| BP | IEP | GO:0072254 | metanephric glomerular mesangial cell differentiation |
| BP | IDA | GO:0098609 | cell-cell adhesion |
| BP | IDA | GO:1900035 | negative regulation of cellular response to heat |
| BP | IDA | GO:1900038 | negative regulation of cellular response to hypoxia |
| BP | IMP | GO:1900041 | negative regulation of interleukin-2 secretion |
| BP | IDA | GO:1900168 | positive regulation of glial cell-derived neurotrophic factor secretion |
| BP | IDA | GO:1901215 | negative regulation of neuron death |
| BP | IDA | GO:2001214 | positive regulation of vasculogenesis |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005764 | lysosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IC | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0009925 | basal plasma membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0036053 | glomerular endothelium fenestra |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: CD34
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD34
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD34
CLASSFICATION
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