CD80
Summary: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD80 molecule | MIM:112203 | Ensembl:ENSG00000121594 | HGNC:HGNC:1700 | PA26239 | 3q13.33 |
GO terms in CD80
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0015026 | coreceptor activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| BP | IBA | GO:0006955 | immune response |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | NAS | GO:0009967 | positive regulation of signal transduction |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0031295 | T cell costimulation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | NAS | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IBA | GO:0042130 | negative regulation of T cell proliferation |
| BP | NAS | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | NAS | GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process |
| BP | NAS | GO:0045627 | positive regulation of T-helper 1 cell differentiation |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IBA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0098636 | protein complex involved in cell adhesion |
Gene expression in normal tissue: CD80
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD80
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD80
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.