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CDC42EP1

Summary: CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
CDC42 effector protein 1	MIM:606084	Ensembl:ENSG00000128283	HGNC:HGNC:17014	PA38430	22q13.1

GO terms in CDC42EP1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0017049	GTP-Rho binding
MF	HDA	GO:0098641	cadherin binding involved in cell-cell adhesion
CC	IBA	GO:0005737	cytoplasm
CC	IBA	GO:0005856	cytoskeleton
CC	IEA	GO:0005856	cytoskeleton
CC	IBA	GO:0005886	plasma membrane
CC	HDA	GO:0005913	cell-cell adherens junction
CC	HDA	GO:0005925	focal adhesion
CC	IEA	GO:0012505	endomembrane system
BP	IBA	GO:0007266	Rho protein signal transduction
BP	IBA	GO:0008360	regulation of cell shape
BP	IDA	GO:0008360	regulation of cell shape
BP	IBA	GO:0030838	positive regulation of actin filament polymerization
BP	IBA	GO:0031274	positive regulation of pseudopodium assembly
BP	IDA	GO:0031274	positive regulation of pseudopodium assembly
BP	IEA	GO:0043547	positive regulation of GTPase activity
BP	IEA	GO:0098609	cell-cell adhesion

Gene expression in normal tissue: CDC42EP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC42EP1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC42EP1

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DATATYPES

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