CEACAM1
Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carcinoembryonic antigen related cell adhesion molecule 1 | MIM:109770 | Ensembl:ENSG00000079385 | HGNC:HGNC:1814 | PA26358 | 19q13.2 |
GO terms in CEACAM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005516 | calmodulin binding |
| MF | ISS | GO:0015125 | bile acid transmembrane transporter activity |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0031005 | filamin binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0046983 | protein dimerization activity |
| MF | IPI | GO:1990782 | protein tyrosine kinase binding |
| BP | NAS | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001558 | regulation of cell growth |
| BP | ISS | GO:0001568 | blood vessel development |
| BP | IDA | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| BP | IMP | GO:0002859 | negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| BP | ISS | GO:0006469 | negative regulation of protein kinase activity |
| BP | ISS | GO:0007155 | cell adhesion |
| BP | ISS | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | NAS | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | ISS | GO:0010594 | regulation of endothelial cell migration |
| BP | ISS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | ISS | GO:0015721 | bile acid and bile salt transport |
| BP | NAS | GO:0016477 | cell migration |
| BP | IDA | GO:0030334 | regulation of cell migration |
| BP | ISS | GO:0030853 | negative regulation of granulocyte differentiation |
| BP | ISS | GO:0032692 | negative regulation of interleukin-1 production |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0035726 | common myeloid progenitor cell proliferation |
| BP | ISS | GO:0038016 | insulin receptor internalization |
| BP | ISS | GO:0038158 | granulocyte colony-stimulating factor signaling pathway |
| BP | ISS | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
| BP | ISS | GO:0043116 | negative regulation of vascular permeability |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0043318 | negative regulation of cytotoxic T cell degranulation |
| BP | IDA | GO:0044319 | wound healing, spreading of cells |
| BP | ISS | GO:0045601 | regulation of endothelial cell differentiation |
| BP | ISS | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| BP | IDA | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | ISS | GO:0051055 | negative regulation of lipid biosynthetic process |
| BP | ISS | GO:0060312 | regulation of blood vessel remodeling |
| BP | ISS | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0090331 | negative regulation of platelet aggregation |
| BP | ISS | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules |
| BP | ISS | GO:1901143 | insulin catabolic process |
| BP | ISS | GO:1903385 | regulation of homophilic cell adhesion |
| BP | ISS | GO:1903670 | regulation of sprouting angiogenesis |
| BP | ISS | GO:2000346 | negative regulation of hepatocyte proliferation |
| BP | ISS | GO:2001214 | positive regulation of vasculogenesis |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005912 | adherens junction |
| CC | ISS | GO:0009925 | basal plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | ISS | GO:0009986 | cell surface |
| CC | TAS | GO:0016020 | membrane |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0016328 | lateral plasma membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | ISS | GO:0030054 | cell junction |
| CC | IEA | GO:0030658 | transport vesicle membrane |
| CC | IEA | GO:0031528 | microvillus membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IDA | GO:0042101 | T cell receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0070821 | tertiary granule membrane |
Gene expression in normal tissue: CEACAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CEACAM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566977 | Fibronectin matrix formation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CEACAM1
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