CELF4


Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CUGBP Elav-like family member 4MIM:612679Ensembl:ENSG00000101489HGNC:HGNC:14015PA2542818q12.2

GO terms in CELF4


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
BPIDAGO:0000380alternative mRNA splicing, via spliceosome
BPIBAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPIDAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPIBAGO:0006376mRNA splice site selection
BPIEAGO:0006376mRNA splice site selection
BPNASGO:0007281germ cell development
BPNASGO:0009792embryo development ending in birth or egg hatching
BPIEAGO:0017148negative regulation of translation
BPIEAGO:0048025negative regulation of mRNA splicing, via spliceosome
BPIDAGO:0048026positive regulation of mRNA splicing, via spliceosome
BPIEAGO:0090394negative regulation of excitatory postsynaptic potential
BPIEAGO:1902866regulation of retina development in camera-type eye
MFNASGO:0000900translation repressor activity, mRNA regulatory element binding
MFIBAGO:0003723RNA binding
MFIBAGO:0003729mRNA binding
MFIEAGO:0003729mRNA binding
MFIDAGO:0036002pre-mRNA binding
MFISSGO:0042835BRE binding

Gene expression in normal tissue: CELF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CELF4


DatabasePathway IDPathway Des.
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CELF4

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