CHRNA3
Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cholinergic receptor nicotinic alpha 3 subunit | MIM:118503 | Ensembl:ENSG00000080644 | HGNC:HGNC:1957 | PA113 | 15q25.1 |
GO terms in CHRNA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | ISS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | TAS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | IBA | GO:0042166 | acetylcholine binding |
| MF | IC | GO:0042166 | acetylcholine binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005892 | acetylcholine-gated channel complex |
| CC | IDA | GO:0005892 | acetylcholine-gated channel complex |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030425 | dendrite |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | ISS | GO:0044853 | plasma membrane raft |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | NAS | GO:0006811 | ion transport |
| BP | ISS | GO:0006940 | regulation of smooth muscle contraction |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IDA | GO:0007165 | signal transduction |
| BP | ISS | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity |
| BP | IEA | GO:0007210 | serotonin receptor signaling pathway |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007271 | synaptic transmission, cholinergic |
| BP | ISS | GO:0007271 | synaptic transmission, cholinergic |
| BP | IBA | GO:0007274 | neuromuscular synaptic transmission |
| BP | IMP | GO:0007399 | nervous system development |
| BP | ISS | GO:0007626 | locomotory behavior |
| BP | ISS | GO:0014056 | regulation of acetylcholine secretion, neurotransmission |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035094 | response to nicotine |
| BP | IMP | GO:0035095 | behavioral response to nicotine |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | ISS | GO:0042391 | regulation of membrane potential |
| BP | ISS | GO:0048814 | regulation of dendrite morphogenesis |
| BP | IBA | GO:0050877 | nervous system process |
| BP | ISS | GO:0060079 | excitatory postsynaptic potential |
| BP | IMP | GO:0060084 | synaptic transmission involved in micturition |
| BP | ISS | GO:0095500 | acetylcholine receptor signaling pathway |
| BP | ISS | GO:1905144 | response to acetylcholine |
Gene expression in normal tissue: CHRNA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRNA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| pharmgkb | PA162355620 | Nicotine Pathway (Chromaffin Cell), Pharmacodynamics |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
| wikipathways | WP1602 | Nicotine Activity on Dopaminergic Neurons |
| wikipathways | WP1603 | Nicotine Activity on Chromaffin Cells |
| smpdb | SMP00431 | Nicotine Action Pathway |
| smpdb | SMP00628 | Nicotine Metabolism Pathway |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-181431 | Acetylcholine binding and downstream events |
| reactome | R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629587 | Highly sodium permeable acetylcholine nicotinic receptors |
| reactome | R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors |
| reactome | R-HSA-629602 | Activation of Nicotinic Acetylcholine Receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRNA3
CLASSFICATION
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