CHST8
Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carbohydrate sulfotransferase 8 | MIM:610190 | Ensembl:ENSG00000124302 | HGNC:HGNC:15993 | PA26508 | 19q13.11 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CHST8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity |
| MF | TAS | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0006790 | sulfur compound metabolic process |
| BP | NAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0016051 | carbohydrate biosynthetic process |
| BP | IDA | GO:0030166 | proteoglycan biosynthetic process |
| BP | IEP | GO:0042446 | hormone biosynthetic process |
Gene expression in normal tissue: CHST8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHST8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi |
| reactome | R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHST8
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