Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

cardiotrophin like cytokine factor 1MIM:607672Ensembl:ENSG00000175505HGNC:HGNC:17412PA14267210611q13.2

GO terms in CLCF1

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0002639positive regulation of immunoglobulin production
BPIBAGO:0007166cell surface receptor signaling pathway
BPISSGO:0007166cell surface receptor signaling pathway
BPISSGO:0007259JAK-STAT cascade
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPNASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPISSGO:0030183B cell differentiation
BPIBAGO:0030890positive regulation of B cell proliferation
BPISSGO:0030890positive regulation of B cell proliferation
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPTASGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPISSGO:0048295positive regulation of isotype switching to IgE isotypes
BPISSGO:0048711positive regulation of astrocyte differentiation
CCIBAGO:0005576extracellular region
CCIDAGO:0005576extracellular region
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0097058CRLF-CLCF1 complex
CCIDAGO:0097058CRLF-CLCF1 complex
CCIBAGO:0097059CNTFR-CLCF1 complex
CCIDAGO:0097059CNTFR-CLCF1 complex
MFIPIGO:0005102signaling receptor binding
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFNASGO:0005125cytokine activity
MFIDAGO:0005127ciliary neurotrophic factor receptor binding
MFIDAGO:0005127ciliary neurotrophic factor receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0008083growth factor activity
MFIDAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: CLCF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLCF1

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6788467IL-6-type cytokine receptor ligand interactions
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLCF1