Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].

claudin 14MIM:605608Ensembl:ENSG00000159261HGNC:HGNC:2035PA2656121q22.13

GO terms in CLDN14

Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005783endoplasmic reticulum
CCHDAGO:0005886plasma membrane
CCISSGO:0005923bicellular tight junction
CCIEAGO:0016021integral component of membrane
BPISSGO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
BPTASGO:0065003protein-containing complex assembly
MFIEAGO:0005198structural molecule activity
MFISSGO:0042802identical protein binding

Gene expression in normal tissue: CLDN14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLDN14

DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-420029Tight junction interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP4239EMT transition in Colorectal Cancer
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLDN14