CLIP3
Summary: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CAP-Gly domain containing linker protein 3 | MIM:607382 | Ensembl:ENSG00000105270 | HGNC:HGNC:24314 | PA162382439 | 19q13.12 |
GO terms in CLIP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0010828 | positive regulation of glucose transmembrane transport |
| BP | IMP | GO:0018230 | peptidyl-L-cysteine S-palmitoylation |
| BP | IMP | GO:0031115 | negative regulation of microtubule polymerization |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0044091 | membrane biogenesis |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | IMP | GO:0045807 | positive regulation of endocytosis |
| BP | IMP | GO:0072321 | chaperone-mediated protein transport |
| BP | ISS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| CC | IEA | GO:0005795 | Golgi stack |
| CC | ISS | GO:0005802 | trans-Golgi network |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005886 | plasma membrane |
| CC | IDA | GO:0031901 | early endosome membrane |
| CC | IDA | GO:0032588 | trans-Golgi network membrane |
| CC | IMP | GO:0032588 | trans-Golgi network membrane |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IDA | GO:0055038 | recycling endosome membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IMP | GO:0008017 | microtubule binding |
| MF | IDA | GO:0035594 | ganglioside binding |
Gene expression in normal tissue: CLIP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLIP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLIP3
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