CNOT3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CCR4-NOT transcription complex subunit 3 | MIM:604910 | Ensembl:ENSG00000088038 | HGNC:HGNC:7879 | PA26674 | 19q13.42 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CNOT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
| BP | IEA | GO:0001829 | trophectodermal cell differentiation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IBA | GO:0017148 | negative regulation of translation |
| BP | IEA | GO:0031047 | gene silencing by RNA |
| BP | IBA | GO:2000036 | regulation of stem cell population maintenance |
| BP | IMP | GO:2000036 | regulation of stem cell population maintenance |
| CC | IBA | GO:0000932 | P-body |
| CC | ISS | GO:0000932 | P-body |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0030014 | CCR4-NOT complex |
| CC | IBA | GO:0030015 | CCR4-NOT core complex |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CNOT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNOT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-429947 | Deadenylation of mRNA |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNOT3
CLASSFICATION
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