Summary: This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016].

contactin 2MIM:190197Ensembl:ENSG00000184144HGNC:HGNC:2172PA266861q32.1

GO terms in CNTN2

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0030246carbohydrate binding
MFTASGO:0042802identical protein binding
MFIEAGO:0043621protein self-association
BPIEAGO:0000226microtubule cytoskeleton organization
BPIEAGO:0007155cell adhesion
BPIEAGO:0007411axon guidance
BPIEAGO:0007413axonal fasciculation
BPIEAGO:0007628adult walking behavior
BPIEAGO:0010954positive regulation of protein processing
BPIEAGO:0021853cerebral cortex GABAergic interneuron migration
BPIEAGO:0022010central nervous system myelination
BPIEAGO:0031133regulation of axon diameter
BPIEAGO:0031623receptor internalization
BPISSGO:0045163clustering of voltage-gated potassium channels
BPIEAGO:0045665negative regulation of neuron differentiation
BPIEAGO:0048168regulation of neuronal synaptic plasticity
BPIEAGO:0048710regulation of astrocyte differentiation
BPIEAGO:0060168positive regulation of adenosine receptor signaling pathway
BPISSGO:0071205protein localization to juxtaparanode region of axon
BPIEAGO:0071206establishment of protein localization to juxtaparanode region of axon
BPIMPGO:0097090presynaptic membrane organization
CCISSGO:0005886plasma membrane
CCIEAGO:0008076voltage-gated potassium channel complex
CCIEAGO:0009986cell surface
CCIEAGO:0031225anchored component of membrane
CCISSGO:0033268node of Ranvier
CCIEAGO:0043025neuronal cell body
CCISSGO:0043209myelin sheath
CCISSGO:0044224juxtaparanode region of axon

Gene expression in normal tissue: CNTN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNTN2

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-447038NrCAM interactions

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNTN2