COPZ2


Summary: This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
coatomer protein complex subunit zeta 2MIM:615526Ensembl:ENSG00000005243HGNC:HGNC:19356PA13486269817q21.32

GO terms in COPZ2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006886intracellular protein transport
BPNASGO:0006886intracellular protein transport
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIBAGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIBAGO:0006891intra-Golgi vesicle-mediated transport
CCTASGO:0000139Golgi membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCNASGO:0005801cis-Golgi network
CCTASGO:0005829cytosol
CCIBAGO:0030126COPI vesicle coat
CCIDAGO:0030126COPI vesicle coat
CCNASGO:0030126COPI vesicle coat
CCTASGO:0030133transport vesicle
CCIEAGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane

Gene expression in normal tissue: COPZ2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COPZ2


DatabasePathway IDPathway Des.
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COPZ2

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