COPZ2
Summary: This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| coatomer protein complex subunit zeta 2 | MIM:615526 | Ensembl:ENSG00000005243 | HGNC:HGNC:19356 | PA134862698 | 17q21.32 |
GO terms in COPZ2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | NAS | GO:0006886 | intracellular protein transport |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IBA | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IBA | GO:0006891 | intra-Golgi vesicle-mediated transport |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | NAS | GO:0005801 | cis-Golgi network |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030126 | COPI vesicle coat |
| CC | IDA | GO:0030126 | COPI vesicle coat |
| CC | NAS | GO:0030126 | COPI vesicle coat |
| CC | TAS | GO:0030133 | transport vesicle |
| CC | IEA | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
Gene expression in normal tissue: COPZ2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COPZ2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COPZ2
CLASSFICATION
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