CTNNBIP1
Summary: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| catenin beta interacting protein 1 | MIM:607758 | Ensembl:ENSG00000178585 | HGNC:HGNC:16913 | PA27014 | 1p36.22 |
GO terms in CTNNBIP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0030877 | beta-catenin destruction complex |
| CC | IDA | GO:0030877 | beta-catenin destruction complex |
| BP | IBA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IMP | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response |
| BP | IBA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0043392 | negative regulation of DNA binding |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0045657 | positive regulation of monocyte differentiation |
| BP | IMP | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter |
| BP | IMP | GO:0072201 | negative regulation of mesenchymal cell proliferation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0070016 | armadillo repeat domain binding |
Gene expression in normal tissue: CTNNBIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTNNBIP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTNNBIP1
CLASSFICATION
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