CYP19A1


Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cytochrome P450 family 19 subfamily A member 1MIM:107910Ensembl:ENSG00000137869HGNC:HGNC:2594PA2709115q21.2

GO terms in CYP19A1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005506iron ion binding
MFTASGO:0008395steroid hydroxylase activity
MFTASGO:0009055electron transfer activity
MFTASGO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
MFTASGO:0019825oxygen binding
MFIDAGO:0020037heme binding
MFIDAGO:0070330aromatase activity
BPIEAGO:0002677negative regulation of chronic inflammatory response
BPTASGO:0006694steroid biosynthetic process
BPTASGO:0006703estrogen biosynthetic process
BPIDAGO:0006710androgen catabolic process
BPIEAGO:0008585female gonad development
BPIEAGO:0010760negative regulation of macrophage chemotaxis
BPTASGO:0016125sterol metabolic process
BPIEAGO:0022900electron transport chain
BPIEAGO:0030540female genitalia development
BPIEAGO:0030879mammary gland development
BPIEAGO:0060065uterus development
BPIEAGO:0060736prostate gland growth
BPIEAGO:0061370testosterone biosynthetic process
BPIDAGO:2000866positive regulation of estradiol secretion
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0016020membrane

Gene expression in normal tissue: CYP19A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP19A1


DatabasePathway IDPathway Des.
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP34Ovarian Infertility Genes
wikipathwaysWP43Oxidation by Cytochrome P450
wikipathwaysWP465Tryptophan metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II
smpdbSMP00068Androgen and Estrogen Metabolism
smpdbSMP0035617-Beta Hydroxysteroid Dehydrogenase III Deficiency
smpdbSMP00565Aromatase deficiency
pharmgkbPA145011117Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
pharmgkbPA145011118Estrogen Metabolism Pathway
pharmgkbPA145011120Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics
humancycPWY-7305superpathway of steroid hormone biosynthesis
humancycPWY-7306estradiol biosynthesis II
humancycPWY66-380estradiol biosynthesis I
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa04913Ovarian steroidogenesis - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1643685Disease
reactomeR-HSA-193144Estrogen biosynthesis
reactomeR-HSA-196071Metabolism of steroid hormones
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211976Endogenous sterols
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5579029Metabolic disorders of biological oxidation enzymes
reactomeR-HSA-5579030Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-8957322Metabolism of steroids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD71Sparfosic acid3
iGMDRD280CYTOCHALASIN B2
iGMDRD945ML2143
iGMDRD512nutlin 32
iGMDRD579PF7502
iGMDRD546BMS-7548073
iGMDRD494Neopeltolide2
iGMDRD523Cyanoquinoline, 113
iGMDRD405PIK-752
iGMDRD414MST-3122
iGMDRD399Selumetinib2
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin2
iGMDRD398Sepantronium2
iGMDRD322FK 8662
iGMDRD271Brefeldin A3
iGMDRD137Indisulam6
iGMDRD121GMX17782
iGMDRD434BMS-5369242
iGMDRD171Pemetrexed3
iGMDRD481Dactolisib1
iGMDRD441TW 371

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP19A1

​​​​