CYP4F11
Summary: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytochrome P450 family 4 subfamily F member 11 | MIM:611517 | Ensembl:ENSG00000171903 | HGNC:HGNC:13265 | PA27120 | 19p13.12 |
GO terms in CYP4F11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004497 | monooxygenase activity |
| MF | IDA | GO:0005504 | fatty acid binding |
| MF | IEA | GO:0005506 | iron ion binding |
| MF | IDA | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| MF | TAS | GO:0020037 | heme binding |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| BP | IDA | GO:0006631 | fatty acid metabolic process |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IDA | GO:0042361 | menaquinone catabolic process |
| BP | IDA | GO:0042376 | phylloquinone catabolic process |
| BP | IEA | GO:0042376 | phylloquinone catabolic process |
| BP | IDA | GO:0042377 | vitamin K catabolic process |
| BP | TAS | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: CYP4F11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP4F11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211935 | Fatty acids |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211958 | Miscellaneous substrates |
| reactome | R-HSA-211979 | Eicosanoids |
| reactome | R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| wikipathways | WP43 | Oxidation by Cytochrome P450 |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP4F11
CLASSFICATION
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