Summary: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

cytochrome P450 family 4 subfamily F member 11MIM:611517Ensembl:ENSG00000171903HGNC:HGNC:13265PA2712019p13.12

GO terms in CYP4F11

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004497monooxygenase activity
MFIDAGO:0005504fatty acid binding
MFIEAGO:0005506iron ion binding
MFIDAGO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
MFTASGO:0020037heme binding
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031090organelle membrane
BPIDAGO:0006631fatty acid metabolic process
BPTASGO:0006954inflammatory response
BPTASGO:0007596blood coagulation
BPIDAGO:0042361menaquinone catabolic process
BPIDAGO:0042376phylloquinone catabolic process
BPIEAGO:0042376phylloquinone catabolic process
BPIDAGO:0042377vitamin K catabolic process
BPTASGO:0055114oxidation-reduction process

Gene expression in normal tissue: CYP4F11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP4F11

DatabasePathway IDPathway Des.
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211935Fatty acids
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211958Miscellaneous substrates
reactomeR-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)
reactomeR-HSA-2142753Arachidonic acid metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8978868Fatty acid metabolism
wikipathwaysWP43Oxidation by Cytochrome P450
wikipathwaysWP702Metapathway biotransformation Phase I and II

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP4F11