DFFA
Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA fragmentation factor subunit alpha | MIM:601882 | Ensembl:ENSG00000160049 | HGNC:HGNC:2772 | PA27254 | 1p36.22 |
GO terms in DFFA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005811 | lipid droplet |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0006309 | apoptotic DNA fragmentation |
| BP | IMP | GO:0032076 | negative regulation of deoxyribonuclease activity |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0061077 | chaperone-mediated protein folding |
| BP | IEA | GO:0070242 | thymocyte apoptotic process |
| BP | IBA | GO:1900118 | negative regulation of execution phase of apoptosis |
| BP | IDA | GO:1900118 | negative regulation of execution phase of apoptosis |
| BP | IDA | GO:1902511 | negative regulation of apoptotic DNA fragmentation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0044183 | protein binding involved in protein folding |
| MF | IMP | GO:0060703 | deoxyribonuclease inhibitor activity |
Gene expression in normal tissue: DFFA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DFFA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140342 | Apoptosis induced DNA fragmentation |
| reactome | R-HSA-211227 | Activation of DNA fragmentation factor |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | setpathway | granzyme a mediated apoptosis pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD314 | Tanespimycin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DFFA
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