DFFB
Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA fragmentation factor subunit beta | MIM:601883 | Ensembl:ENSG00000169598 | HGNC:HGNC:2773 | PA27255 | 1p36.32 |
GO terms in DFFB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004536 | deoxyribonuclease activity |
| MF | IMP | GO:0004536 | deoxyribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IMP | GO:0042802 | identical protein binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IMP | GO:0006308 | DNA catabolic process |
| BP | IBA | GO:0006309 | apoptotic DNA fragmentation |
| BP | IDA | GO:0006309 | apoptotic DNA fragmentation |
| BP | TAS | GO:0006309 | apoptotic DNA fragmentation |
| BP | IDA | GO:0030263 | apoptotic chromosome condensation |
| BP | IMP | GO:0051260 | protein homooligomerization |
Gene expression in normal tissue: DFFB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DFFB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | setpathway | granzyme a mediated apoptosis pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140342 | Apoptosis induced DNA fragmentation |
| reactome | R-HSA-211227 | Activation of DNA fragmentation factor |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DFFB
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