DHFR2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dihydrofolate reductase 2 | MIM:616588 | Ensembl:ENSG00000178700 | HGNC:HGNC:27309 | PA134889916 | 3q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DHFR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006730 | one-carbon metabolic process |
| BP | IDA | GO:0046105 | thymidine biosynthetic process |
| BP | IBA | GO:0046452 | dihydrofolate metabolic process |
| BP | IDA | GO:0046653 | tetrahydrofolate metabolic process |
| BP | IBA | GO:0046654 | tetrahydrofolate biosynthetic process |
| BP | IEA | GO:0046654 | tetrahydrofolate biosynthetic process |
| BP | IBA | GO:0046655 | folic acid metabolic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IMP | GO:0005743 | mitochondrial inner membrane |
| CC | IMP | GO:0005759 | mitochondrial matrix |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0004146 | dihydrofolate reductase activity |
| MF | IMP | GO:0004146 | dihydrofolate reductase activity |
| MF | IBA | GO:0050661 | NADP binding |
Gene expression in normal tissue: DHFR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DHFR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196757 | Metabolism of folate and pterines |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| wikipathways | WP2525 | Trans-sulfuration and one carbon metabolism |
| wikipathways | WP3940 | One carbon metabolism and related pathways |
| humancyc | PWY66-385 | dTMP de novo biosynthesis (mitochondrial) |
| kegg | hsa00670 | One carbon pool by folate - Homo sapiens (human) |
| kegg | hsa00790 | Folate biosynthesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DHFR2
CLASSFICATION
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