DIMT1
Summary: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
DIM1 dimethyladenosine transferase 1 homolog | MIM:612499 | Ensembl:ENSG00000086189 | HGNC:HGNC:30217 | PA162383599 | 5q12.1 |
GO terms in DIMT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | EXP | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
MF | IBA | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
MF | IMP | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity |
MF | HDA | GO:0003723 | RNA binding |
MF | IEA | GO:0052909 | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
CC | IDA | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005730 | nucleolus |
CC | IBA | GO:0005759 | mitochondrial matrix |
CC | IDA | GO:0005829 | cytosol |
BP | IBA | GO:0031167 | rRNA methylation |
BP | IMP | GO:0031167 | rRNA methylation |
BP | TAS | GO:0031167 | rRNA methylation |
BP | IMP | GO:2000234 | positive regulation of rRNA processing |
Gene expression in normal tissue: DIMT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DIMT1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-6790901 | rRNA modification in the nucleus and cytosol |
reactome | R-HSA-72312 | rRNA processing |
reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DIMT1