DIMT1


Summary: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DIM1 dimethyladenosine transferase 1 homologMIM:612499Ensembl:ENSG00000086189HGNC:HGNC:30217PA1623835995q12.1

GO terms in DIMT1


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity
MFIBAGO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity
MFIMPGO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity
MFHDAGO:0003723RNA binding
MFIEAGO:005290918S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0005759mitochondrial matrix
CCIDAGO:0005829cytosol
BPIBAGO:0031167rRNA methylation
BPIMPGO:0031167rRNA methylation
BPTASGO:0031167rRNA methylation
BPIMPGO:2000234positive regulation of rRNA processing

Gene expression in normal tissue: DIMT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DIMT1


DatabasePathway IDPathway Des.
reactomeR-HSA-6790901rRNA modification in the nucleus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DIMT1

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