DMAP1
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA methyltransferase 1 associated protein 1 | MIM:605077 | Ensembl:ENSG00000178028 | HGNC:HGNC:18291 | PA134927315 | 1p34.1 |
GO terms in DMAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005657 | replication fork |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0035267 | NuA4 histone acetyltransferase complex |
| CC | IDA | GO:0035267 | NuA4 histone acetyltransferase complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006281 | DNA repair |
| BP | TAS | GO:0006306 | DNA methylation |
| BP | IEA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IDA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IBA | GO:0043967 | histone H4 acetylation |
| BP | IDA | GO:0043967 | histone H4 acetylation |
| BP | IBA | GO:0043968 | histone H2A acetylation |
| BP | IDA | GO:0043968 | histone H2A acetylation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | NAS | GO:0045892 | negative regulation of transcription, DNA-templated |
Gene expression in normal tissue: DMAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DMAP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DMAP1
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