DOCK5
Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dedicator of cytokinesis 5 | MIM:616904 | Ensembl:ENSG00000147459 | HGNC:HGNC:23476 | PA134932307 | 8p21.2 |
GO terms in DOCK5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IMP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IMP | GO:1904694 | negative regulation of vascular smooth muscle contraction |
| BP | IMP | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| MF | ISS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: DOCK5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DOCK5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DOCK5
CLASSFICATION
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