Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].

dual specificity phosphatase 3MIM:600183Ensembl:ENSG00000108861HGNC:HGNC:3069PA2752617q21.31

GO terms in DUSP3

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0001772immunological synapse
BPIMPGO:0000188inactivation of MAPK activity
BPIEAGO:0001701in utero embryonic development
BPIDAGO:0035335peptidyl-tyrosine dephosphorylation
BPIMPGO:0043409negative regulation of MAPK cascade
BPIBAGO:0045931positive regulation of mitotic cell cycle
BPIMPGO:0045931positive regulation of mitotic cell cycle
BPIBAGO:0046329negative regulation of JNK cascade
BPIDAGO:0046329negative regulation of JNK cascade
BPIMPGO:0046329negative regulation of JNK cascade
BPIBAGO:0050860negative regulation of T cell receptor signaling pathway
BPIDAGO:0050860negative regulation of T cell receptor signaling pathway
BPIBAGO:0050868negative regulation of T cell activation
BPIDAGO:0050868negative regulation of T cell activation
BPIBAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIDAGO:0070373negative regulation of ERK1 and ERK2 cascade
MFIDAGO:0004725protein tyrosine phosphatase activity
MFTASGO:0004725protein tyrosine phosphatase activity
MFIDAGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFIMPGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFIDAGO:0016791phosphatase activity
MFIDAGO:0019901protein kinase binding
MFIBAGO:0033549MAP kinase phosphatase activity
MFIMPGO:0033549MAP kinase phosphatase activity

Gene expression in normal tissue: DUSP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DUSP3

DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
wikipathwaysWP382MAPK Signaling Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-202670ERKs are inactivated
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DUSP3