DYNLT3


Summary: This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dynein light chain Tctex-type 3MIM:300302Ensembl:ENSG00000165169HGNC:HGNC:11694PA36414Xp11.4

Gene Categories:

TUMOR SUPPRESSOR

GO terms in DYNLT3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003774motor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
CCIDAGO:0000776kinetochore
CCIEAGO:0000777condensed chromosome kinetochore
CCIEAGO:0005634nucleus
CCIDAGO:0005868cytoplasmic dynein complex
CCIEAGO:0061673mitotic spindle astral microtubule
BPIEAGO:0007049cell cycle
BPISSGO:0007346regulation of mitotic cell cycle
BPIEAGO:0045931positive regulation of mitotic cell cycle
BPIEAGO:0051301cell division

Gene expression in normal tissue: DYNLT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DYNLT3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYNLT3

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