DYNLT3
Summary: This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
dynein light chain Tctex-type 3 | MIM:300302 | Ensembl:ENSG00000165169 | HGNC:HGNC:11694 | PA36414 | Xp11.4 |
Gene Categories:
TUMOR SUPPRESSORGO terms in DYNLT3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003774 | motor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0042802 | identical protein binding |
CC | IDA | GO:0000776 | kinetochore |
CC | IEA | GO:0000777 | condensed chromosome kinetochore |
CC | IEA | GO:0005634 | nucleus |
CC | IDA | GO:0005868 | cytoplasmic dynein complex |
CC | IEA | GO:0061673 | mitotic spindle astral microtubule |
BP | IEA | GO:0007049 | cell cycle |
BP | ISS | GO:0007346 | regulation of mitotic cell cycle |
BP | IEA | GO:0045931 | positive regulation of mitotic cell cycle |
BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: DYNLT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DYNLT3
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYNLT3