DYRK1A


Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dual specificity tyrosine phosphorylation regulated kinase 1AMIM:600855Ensembl:ENSG00000157540HGNC:HGNC:3091PA2754521q22.13

GO terms in DYRK1A


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFIGIGO:0004674protein serine/threonine kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004712protein serine/threonine/tyrosine kinase activity
MFISSGO:0004713protein tyrosine kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0042802identical protein binding
MFISSGO:0043621protein self-association
MFISSGO:0048156tau protein binding
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCISSGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005856cytoskeleton
CCISSGO:0016607nuclear speck
CCTASGO:0016607nuclear speck
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCIEAGO:1990904ribonucleoprotein complex
BPIEAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPISSGO:0006468protein phosphorylation
BPTASGO:0006468protein phosphorylation
BPTASGO:0007399nervous system development
BPISSGO:0007623circadian rhythm
BPIEAGO:0016032viral process
BPIGIGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018107peptidyl-threonine phosphorylation
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0031115negative regulation of microtubule polymerization
BPIDAGO:0033120positive regulation of RNA splicing
BPIMPGO:0034205amyloid-beta formation
BPTASGO:0036289peptidyl-serine autophosphorylation
BPIDAGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038083peptidyl-tyrosine autophosphorylation
BPISSGO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator
BPISSGO:0046777protein autophosphorylation
BPIEAGO:0048025negative regulation of mRNA splicing, via spliceosome
BPISSGO:0090312positive regulation of protein deacetylation

Gene expression in normal tissue: DYRK1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DYRK1A


DatabasePathway IDPathway Des.
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
netpathPathway_EGFR1EGFR1
netpathPathway_HedgehogHedgehog
netpathPathway_TCRTCR
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69278Cell Cycle, Mitotic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD260FQI-21
iGMDRD158NSC1415403
iGMDRD6AM-5803
iGMDRD506Fedratinib1
iGMDRD871BRD63686
iGMDRD356PNU-746543
iGMDRD64Parbendazole1
iGMDRD248BRD43541
iGMDRD433Lexibulin4
iGMDRD151CHM-13
iGMDRD546BMS-7548076
iGMDRD779PRL-3 Inhibitor I3
iGMDRD193Fqi13
iGMDRD639YK 4-2793
iGMDRD446LY 21832403
iGMDRD394BX-7954
iGMDRD123Isoevodiamine1
iGMDRD280CYTOCHALASIN B1
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYRK1A

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