DYRK1B
Summary: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity tyrosine phosphorylation regulated kinase 1B | MIM:604556 | Ensembl:ENSG00000105204 | HGNC:HGNC:3092 | PA27549 | 19q13.2 |
GO terms in DYRK1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007520 | myoblast fusion |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0060612 | adipose tissue development |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: DYRK1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 1 |
| iGMDRD781 | Sirolimus | 7 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYRK1B
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.