DYRK4
Summary: This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity tyrosine phosphorylation regulated kinase 4 | MIM:609181 | Ensembl:ENSG00000010219 | HGNC:HGNC:3095 | PA27552 | 12p13.32 |
GO terms in DYRK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: DYRK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD630 | ML203 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYRK4
CLASSFICATION
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