EPHB2


Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor B2MIM:600997Ensembl:ENSG00000133216HGNC:HGNC:3393PA278251p36.12

GO terms in EPHB2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001540amyloid-beta binding
MFIBAGO:0004709MAP kinase kinase kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFISSGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFISSGO:0005005transmembrane-ephrin receptor activity
MFTASGO:0005005transmembrane-ephrin receptor activity
MFIEAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008046axon guidance receptor activity
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIEAGO:0042802identical protein binding
MFISSGO:0044877protein-containing complex binding
BPISSGO:0001525angiogenesis
BPISSGO:0001655urogenital system development
BPISSGO:0001933negative regulation of protein phosphorylation
BPIBAGO:0007275multicellular organism development
BPTASGO:0007399nervous system development
BPISSGO:0007411axon guidance
BPISSGO:0007413axonal fasciculation
BPISSGO:0007611learning or memory
BPISSGO:0007612learning
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0016310phosphorylation
BPISSGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021631optic nerve morphogenesis
BPIEAGO:0021952central nervous system projection neuron axonogenesis
BPISSGO:0022038corpus callosum development
BPIBAGO:0030154cell differentiation
BPIEAGO:0031290retinal ganglion cell axon guidance
BPISSGO:0031915positive regulation of synaptic plasticity
BPIBAGO:0033674positive regulation of kinase activity
BPISSGO:0042472inner ear morphogenesis
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0046580negative regulation of Ras protein signal transduction
BPISSGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPISSGO:0048168regulation of neuronal synaptic plasticity
BPIEAGO:0048170positive regulation of long-term neuronal synaptic plasticity
BPIEAGO:0048593camera-type eye morphogenesis
BPIEAGO:0050771negative regulation of axonogenesis
BPISSGO:0050878regulation of body fluid levels
BPISSGO:0051389inactivation of MAPKK activity
BPISSGO:0051965positive regulation of synapse assembly
BPISSGO:0060021roof of mouth development
BPISSGO:0060996dendritic spine development
BPISSGO:0060997dendritic spine morphogenesis
BPISSGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0071679commissural neuron axon guidance
BPIBAGO:0099557trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
BPIEAGO:0099557trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
BPIEAGO:0106028neuron projection retraction
BPIBAGO:1900273positive regulation of long-term synaptic potentiation
BPISSGO:1900273positive regulation of long-term synaptic potentiation
BPISSGO:1903078positive regulation of protein localization to plasma membrane
BPISSGO:1904782negative regulation of NMDA glutamate receptor activity
BPISSGO:1904783positive regulation of NMDA glutamate receptor activity
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCIBAGO:0043005neuron projection
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCTASGO:0098794postsynapse

Gene expression in normal tissue: EPHB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHB2


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
pidephbfwdpathwayEPHB forward signaling
pidephrinbrevpathwayEphrin B reverse signaling
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
kegghsa04360Axon guidance - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_EGFR1EGFR1
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP288NLR Proteins
wikipathwaysWP3Transcriptional activation by NRF2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD506Fedratinib3
iGMDRD562Navitoclax3
iGMDRD286Nsc 6328393
iGMDRD874BRD89581
iGMDRD268Cerulenin2
iGMDRD300Tozasertib3
iGMDRD158NSC1415403
iGMDRD137Indisulam3
iGMDRD318PAC-16
iGMDRD105Triptolide3
iGMDRD782DC-45-A23
iGMDRD152179324-69-74
iGMDRD634SCHEMBL26080413
iGMDRD154NSC237663
iGMDRD394BX-7953
iGMDRD512nutlin 33
iGMDRD126Tipifarnib7
iGMDRD84Lovastatin acid3
iGMDRD781Sirolimus3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHB2

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