Summary: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008].

FAT atypical cadherin 2MIM:604269Ensembl:ENSG00000086570HGNC:HGNC:3596PA280095q33.1

GO terms in FAT2

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005886plasma membrane
CCIDAGO:0005913cell-cell adherens junction
CCIEAGO:0016021integral component of membrane
CCHDAGO:0070062extracellular exosome
BPISSGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIMPGO:0010631epithelial cell migration
MFIEAGO:0005509calcium ion binding

Gene expression in normal tissue: FAT2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FAT2

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FAT2