FBXW5
Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| F-box and WD repeat domain containing 5 | MIM:609072 | Ensembl:ENSG00000159069 | HGNC:HGNC:13613 | PA134928070 | 9q34.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in FBXW5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0019005 | SCF ubiquitin ligase complex |
| CC | IDA | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IMP | GO:0010824 | regulation of centrosome duplication |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0043687 | post-translational protein modification |
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: FBXW5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FBXW5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| netpath | Pathway_IL1 | IL1 |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FBXW5
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