Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008].

F-box and WD repeat domain containing 5MIM:609072Ensembl:ENSG00000159069HGNC:HGNC:13613PA1349280709q34.3

Gene Categories:


GO terms in FBXW5

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0019005SCF ubiquitin ligase complex
CCIDAGO:0080008Cul4-RING E3 ubiquitin ligase complex
BPTASGO:0000209protein polyubiquitination
BPIEAGO:0007088regulation of mitotic nuclear division
BPIMPGO:0010824regulation of centrosome duplication
BPIDAGO:0016567protein ubiquitination
BPIDAGO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPTASGO:0043687post-translational protein modification
MFEXPGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: FBXW5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBXW5

DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBXW5