FCGR1B


Summary: Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Fc fragment of IgG receptor IbMIM:601502Ensembl:ENSG00000198019HGNC:HGNC:3614PA280611p11.2

GO terms in FCGR1B


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0019763immunoglobulin receptor activity
MFIEAGO:0019864IgG binding
CCNASGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030669clathrin-coated endocytic vesicle membrane
CCTASGO:0031901early endosome membrane
BPIEAGO:0002250adaptive immune response
BPTASGO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BPTASGO:0006898receptor-mediated endocytosis
BPNASGO:0006955immune response
BPIEAGO:0038093Fc receptor signaling pathway
BPTASGO:0060333interferon-gamma-mediated signaling pathway

Gene expression in normal tissue: FCGR1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCGR1B


DatabasePathway IDPathway Des.
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)
reactomeR-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD608Refametinib1
iGMDRD152179324-69-71
iGMDRD352PD-03259011
iGMDRD670ML 2101
iGMDRD546BMS-7548071
iGMDRD574Ruxolitinib1
iGMDRD1037X1S.3R.RSL.31
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD186SMER31
iGMDRD251ML1621
iGMDRD208Necrosulfonamide1
iGMDRD12Bicalutamide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR1B

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